This paper looks at different ways to handle uncertainty, which is inherent in projects, and how interdependencies between these projects can be found and utilized. The content is based on an extensive literature survey on real options and project management. The last part of the paper presents a method how to use networks to visualize positive and negative synergies. The main findings are that real option analysis is a powerful tool for pricing projects, but when the number of interrelated projects grows it is uncertain if the existing methods can be used. Some pharmaceuptical companies appear to have good methods for finding synergies and handling uncertainly with the help of scenarios. Finally it appears as if network analysis has a lot of potential for analyzing the problems of synergies and uncertainty, but a present there does not seem to exist any software for this type of analysis.