Annual report 2003 on FOI's research on weapon's traumatology
Publish date: 2004-01-01
Report number: FOI-R--1144--SE
Pages: 19
Written in: Swedish
Abstract
During 2003, the Weapon´s traumatology program has consisted of the following research projects: Weapon effects on CNS (= central nervous system), Weapon effects on cells, Wound ballistics and human protection and Biomedical effects of underwater explosions. Integration of biomedicine and technology has continued, especially within the two latter projects. The previous project Weapon effects on humans was discontinued 2002, but a part of this research has been transferred to Wound ballistics and human protection. A number of research reports as well as scientific papers have been published. Presentations have been given at several scientific meetings, nationally and internationally. Four report seminars have been arranged for the customer. Important scientific findings during the year are: 1/Penetrating brain injuries, but not mild concussions, are followed by an increase of the protein S-100 in serum. This is partly connected to lesion-induced defects in the blood-brain barrier. 2/Impulse noise-induced changes in hearing threshold can be partly prevented by antioxidant treatment. 3/Exposure to high power microwaves (HPM) is followed by degradation of the cytoskeleton protein tubulin and upregulation of VEGF in endothelial and neuroblastoma cells. 4/Effects on the brain´s electrical activity were demonstrated (EEG) efter exposure to under water shock waves. This can be relevant for the evaluation of risk of drowning during operations including under water blasts. 5/A standardized experimental model for Behind Armour Blunt Trauma (BABT) was developed, which can be used for evaluation of pathophysiological mechanisms as well as for treatment efficacy studies. The model has been successfully used with two different resuscitation regimes.