Improved sample preparation for determination of phosphoramidates in water samples based on Na+ cat-ion exchange

Authors:

  • Åstot Crister
  • Nygren Yvonne
  • Fredriksson Sten-Åke
  • Hammarström Lars-Gunnar
  • Nilsson Calle

Publish date: 2006-01-01

Report number: FOI-R--1988--SE

Pages: 9

Written in: English

Keywords:

  • Chemical warfare agents
  • Phosphoramidate
  • Sample preparation
  • Cat-ion exchange
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Abstract

A new (Na+) cat-ion exchange method for CWA sample preparation was evaluated. The new method prevents the acidification of samples associated with the use of exchangers in H+-mode. The acidification may induce hydrolysis if sensitive chemicals are contained in samples of high salinity. During "the 14th OPCW Proficiency Test" this problem was observed when a phosphoramidate was hydrolysed during sample preparation according to the standard cat-ion exchange method. Use of the new method was shown to prevent this degradation.