The aim of the project has been to increase the understanding of systemic uptake of nerve agents after dermal exposure and to identify best possible procedures for medical treatment. The knowledge has been communicated to the Armed Forces and the National Board of Health and Welfare through specific reports and by oral presentations. Research has been conducted in order to explore the risk for toxic effects following skin deposition of low volatile nerve agents such as VX and to evaluate procedures for skin decontamination. The results have shown that addition of water to neat VX (e.g. by extensive sweating) significantly enhances the penetration through skin. Different methods for decontamination of VX have been compared and an optimized protocol for decontamination of VX using Reactive Skin Decontamination Lotion (RSDL) has been identified. Experimental methods have been developed to enable studies of cholinergic reactions in isolated tissues and cells following nerve agent exposure. These models have been used to evaluate the efficacy of medical countermeasures, mainly substances with anticholinergic activities.