The EDA project Energetic Materials Production, Obsolescence and Formulation (EMPOF) includes a work package on the development of continuous production technology for energetic materials. This project is a part of EMPOF, which occurs in collaboration with the R&D project Energetic Systems from the Swedish Armed Forces, and aims to nationally and within the EU secure the supply of critical energetic materials. The plasticizer n-butylnitratoethylnitramine (BuNENA) is one of these critical products. The project will develop and demonstrate a manufacturing method and a production facility for the production of BuNENA based on flow chemistry. Manufacturing of BuNENA was investigated on a smaller scale for optimized purity and yield. Factorial design was used to analyze how the included parameters affected purity and yield. Two different parameter settings were selected for the further development of the continuous production plant.